Sibutramine is a drug produced since 1997 and used as adjunctive treatment for nutritional obesity. It is a phenylethylamine anorectic that causes a change in brain amines resulting in decreased appetite and a feeling of fullness.
Sibutramine acts by inhibiting the reuptake of serotonin and norepinephrine. But, unlike Fenfluramine and its derivatives, it does not increase the level of circulating serotonin and therefore would not have the cardiac side effects of the latter. It increases the feeling of satiety and therefore reduces food intake. Sibutramine is particularly effective, it acts from the start of the cycle (after only 2/3 days).
It is not recommended to exceed 12 months of treatment and to use Sibutramine if you have a cardiovascular history.